diff --git a/.gitignore b/.gitignore
index 3bd50e100..b42395efb 100644
--- a/.gitignore
+++ b/.gitignore
@@ -7,6 +7,7 @@
 *.exe.manifest
 build/
 test/work/
+interfaces/cython/cantera/_cantera.h
 include/cantera/base/config.h
 include/cantera/ext/
 interfaces/matlab/ctpath.m
diff --git a/SConstruct b/SConstruct
index 1106fc078..a17f6582a 100644
--- a/SConstruct
+++ b/SConstruct
@@ -62,6 +62,7 @@ if 'clean' in COMMAND_LINE_TARGETS:
     removeFile('include/cantera/base/config.h')
     removeDirectory('include/cantera/ext')
     removeFile('interfaces/cython/cantera/_cantera.cpp')
+    removeFile('interfaces/cython/cantera/_cantera.h')
     removeFile('interfaces/cython/setup2.py')
     removeFile('interfaces/cython/setup3.py')
     removeFile('interfaces/python_minimal/setup.py')