diff --git a/interfaces/cython/SConscript b/interfaces/cython/SConscript
index 67b684136..83628d76c 100644
--- a/interfaces/cython/SConscript
+++ b/interfaces/cython/SConscript
@@ -101,11 +101,11 @@ elif localenv['python_prefix']:
         extra = ''
     elif localenv['OS'] == 'Darwin':
         extra = localenv.subst(' --prefix=${python_prefix}')
-    elif localenv['libdirname'] == 'lib64':
-        # 64-bit RHEL / Fedora
+    elif localenv['libdirname'] != 'lib':
+        # 64-bit RHEL / Fedora etc. or e.g. x32 Gentoo profile
         extra = localenv.subst(
             ' --prefix=${python_prefix}'
-            ' --install-lib=${python_prefix}/lib64/python{}/site-packages'.format(py_version))
+            ' --install-lib=${{python_prefix}}/${{libdirname}}/python{}/site-packages'.format(py_version))
     else:
         extra = '--user'
         localenv.AppendENVPath(